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세션명 Korea-Taiwan Joint Symposium: Emerging Technology in Polymer Science (English)
발표장 삼다홀A
논문코드 1L1-8
발표일 2019-10-10
발표시간 16:45-17:10
논문제목 An Engineering Approach for Sustainable Peptide Synthesis
발표자 Sheng-Sheng Yu
발표자 소속 Department of Chemical Engineering, National Cheng Kung University
저자 Sheng-Sheng Yu, Chen-Yu Chien, Chun-Wei Lai
소속 Department of Chemical Engineering, National Cheng Kung University
논문초록 The synthesis of polypeptides has been a long-standing problem in the field of prebiotic chemistry and pharmaceutical industries. Direct peptide bond formation will not occur unless high temperature or activating agents are used because of the high activation energies. Here, we found a simple system composed of hydroxy acids and amino acids that is capable of forming peptide bonds under mild conditions. Hydroxy acids form metastable oligoesters in the oscillating (hot dry/cool wet) system and transform into mixed copolymers via the ester-amide exchange reaction. A mathematical model was developed to evaluate the kinetic behavior of the copolymerization. Finally, we found that the complexity of the copolymers can be further reduced by using deep eutectic solvents as a green media. Besides our work in polypeptides synthesis, this presentation will introduce other ongoing work of our group, such as developing sustainable inks for 3D printing based on deep eutectic solvents.