| 세션명 | 대학원생 구두발표 (I) |
|---|---|
| 발표장 | 302호 |
| 논문코드 | 1O11-8 |
| 발표일 | 2019-10-10 |
| 발표시간 | 15:15-15:30 |
| 논문제목 | pH sensitivity microgel with Methacrylic acid for highly efficient targeted drug delivery |
| 발표자 | 이현아 |
| 발표자 소속 | 서울과학기술대학교 |
| 저자 | 이현아, 노혜란†, 김명지, 신혜영 |
| 소속 | 서울과학기술대학교 |
| 논문초록 | Multifunctional polymeric drug carriers for optometrical uses have been intensively studied for the last decades, as it readily allows for a stimuli-responsive or sustained release of pharmaceutical agents. Herein, we describe fabrication of a micro-sized pH-responsive drug carrier, morphological, kinetic analysis, and consistency assessment. The microgel was prepared by copolymerizing N-isopropylacrylamide with methacrylic acid. Time-based release experiments were performed in a pH range reflected physiological conditions of dry and normal eyes (pH 6.9 - 7.9) We tagged the hyaluronic acids with a fluorescent dye to better trace the drug molecules and to obtain reliable kinetic data in a pH range of physiological conditions. As a result, the release amounts at basic condition significantly increased. Comprehensively, this complex can markedly enhance pharmaceutical effects during a long-term medication for dry eye syndrome. |
THE POLYMER SOCIETY OF KOREA