연구논문 초록집

초록 검색

세션명 기능성 고분자(III)
발표장 포스터장
논문코드 3PS-224
발표일 2019-10-11
발표시간 16:00-17:30 (게시시간: 13:50-17:30)
논문제목 In-situ Cell Monitoring Upon Exposure to an Anti-cancer Drug in the Functionalized Microfluidic Chip
발표자 김다름
발표자 소속 충남대학교
저자 김다름, 이수진, 양성윤
소속 충남대학교
논문초록 We have fabricated a micro-fluidic biochip which has the surface functionalized cell binding ability and real time monitoring of drug afficacy. For this study, an anticancer drug was encapsulated in the hydrogel beads placed within the micro-channels of the chip. We modified the micro-channel surfaces by layer-by-layer (LbL) deposition with polymers in order to provide efficient cell culturing condition. The LbL coating was locally applied on the areas of the channel which enabled the covninient cellular toxicity monitoting. We also tested the drug afficacy toward cancer cells over normal cells. The results of this study indicate that the micro-channels suitably surface functionalized might be available to effectively monitor cancerous cells upon the exposure to anti-cancer drug in microfluidic chips.